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H.ZetterbergH.SanoM.JohannsenP.et al

Low daily activity limits total calories burned, causing progress to stall despite proper medication use

There are also concerns around quality control as more generics enter the market

3 January 2018

## What the Research Says About Missed Doses and Breaks ### The STEP 4 Study: What Happens When You Stop The STEP 4 trial, published in *JAMA* (2021), provided the most direct evidence of what happens when semaglutide is discontinued: - Participants took semaglutide for 20 weeks, then were randomized to either continue or switch to placebo - Those who continued lost an additional 7.9% body weight over the next 48 weeks - Those who switched to placebo **regained approximately two-thirds** of their lost weight within one year - Metabolic improvements (blood sugar, cholesterol, blood pressure) also partially reversed **Key takeaway**: Consistent dosing is essential for maintaining results