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All of these showed efficacy in animal models

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Promote resolution of acute inflammation (shifting from pro-inflammatory to pro-repair signals) while reducing chronic pathological inflammation

BPC-157 (Body Protection Compound-157, CAS 137525-51-2) is a synthetic pentadecapeptide of 15 amino acids (sequence GEPPPGKPADDAGLV), a stable fragment of the BPC protein isolated from human gastric juice

Best used by: Those whose dark circles have a brownish pigmentation component that conventional eye brighteners have not adequately addressed, and anyone whose discolouration around the eyes combines both pigmentation and vascular elements and needs a single formula addressing both