To date, observational studies investigating the cardiovascular effectiveness of the combination have either been underpowered or had important methodological limitations, such as immortal time bias.1215181920 Importantly, none compared the combination with either drug class alone or investigated serious renal events, which are clinically relevant outcomes in this patient population.1215181920 The primary objective of this study was to determine whether the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors is associated with a decreased risk of two co-primary outcomes, major adverse cardiovascular events and serious renal events, compared with the use of either drug class alone among patients with type 2 diabetes
The weight can still go back up." Cost is another important consideration
You should also discuss the cost, potential side effects, and any concerns you may have
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L., Wang, Y., and Wang, M
