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Additionally, if gut permeability is indeed increased in ME/CFS patients, microbes and antigens may be able to cross the epithelial barrier into surrounding tissue and blood, potentially crossing the BBB and altering the HPA axis (443)

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Protocols lasting 812 weeks show measurably better tissue outcomes when injection timing aligns with researcher workflow patterns that ensure zero missed doses, compared to theoretically optimal but inconvenient schedules that introduce gaps