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Current Genetics
clear solution when dissolved 1% in water
neurotoxicity
Time course design should account for rapid transcriptional changes
β-Nap-β-D-Gal
Gefitinib N125 Current GeneticsGefitinib is an anti cancer agent similar to erlotinib. It functions through inhibiting the overexpressed or mutated epidermal growth factor receptor (EGFR) by binding its ATP binding site. Overexpression and mutation of EGFR are common in cancer cell lines and may lead to uncontrolled proliferation through the Ras signaling cascade. Gefitinib has been shown to induce tumor cell apoptosis in HaCaT cells, KG 1 cells, P39 cells, and CD34+ myeloblasts.
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