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Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function

Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the receptor every GLP-1 compound targets), MC4R (central to satiety and energy balance), and TCF7L2 (tied to glucose homeostasis) describe your baseline metabolic terrain

each R 4 is independently selected from F, Br, I, CN, NO 2 , OR 9 , OCF 3 , NR 8 R 9 , C(O)NR 8 R 9 , N(R 8 )C(O)R 10 , N(R 8 )CO 2 R 10 , NHS(O) 2 R 10 , S(O) 2 NR 8 R 9 , C 2 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, and C 3 -C 9 heteroaryl

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