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For KPV dosing , oral administration makes particular sense for gastrointestinal autoimmune conditions because the PepT1 transporter directly facilitates absorption in inflamed intestinal tissue

If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase

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Psychiatry 47 ImaiH.MatsuokaM.KumagaiT.SakamotoT.KoumuraT

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