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We already know the short-term side effects that patients taking these drugs to lose weight have experienced: nausea, vomiting, bloating, and some more extreme (albeit rare) things like bowel obstruction, pancreatitis, and stomach paralysis

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We review your medical history to avoid risk for patients with bleeding disorders, neurological conditions, or allergies

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However, the de-pigmenting effects at the presence of 0.1, 1 and 10 mM of -arbutin are individually much lower than that of 50 M T1