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Vitamin B12 Why it matters: Found naturally in animal foods, vitamin B12 regulates key metabolic processes in the body both directly and as a cofactor (or "helper molecule") for two enzymes (methionine synthase and L-methylmalonyl-coenzyme A mutase)

Reduces Bone Resorption: Lowers bone turnover markers and helps preserve bone mineral density in androgen-deficient states 4

Nicholas MP, Mysore N

This opens up a whole new pathway for communication. Hayes says researchers are now looking into how much GLP-1 gets in, where exactly the drugs go, and what behaviors or functions they cause

Gastrointestinal burden Retatrutide already produces significant GI side effects