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NRF2 is very pleiotropic and there is redundancy in its transcriptional output, therefore targeting of specific NRF2 targets has been therapeutically ineffective

A 7-day course of AmB (1 mg/kg/day) with 5-FC (100 mg/kg/day) yields the lowest 10-week mortality (24.2%), with 5-FC outperforming fluconazole (Day et al., 2013

Gu et al., 2023)

Trends Biotechnol 22:123129