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the joints can ache even at rest Other rheumatoid symptoms include: A feeling of warmth around the joint Symptoms throughout the body, such as fever, loss of appetite, and decreased energy Weakness due to a low red blood cell count (anemia) Nodules, or lumps, especially around the elbow Deformities and contractures of the joint (with long-lasting disease) Foot pain, bunions, and hammer toes (with long-lasting disease) Patients with severe rheumatoid arthritis typically have multiple affected joints in the hands, arms, legs, and feet

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P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells