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Ann Int Med 164(11) June 7, 2016 doi:10.7326/M15-2650 Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

Studies in rodent models and suicide victims

In most cases, no treatment or treatment with diphenhydramine alone or with salbutamol was sufficient to continue or restart NAC infusion safely

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Formulation choices vehicle, pH, penetration enhancers, concentration, and whether the peptide is stabilized against degradation can make the difference between a product that delivers an active dose and one that mostly sits on the surface