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PCA indicated that the metabolomic profiles clustered by both smoking status and bacterial community state type (CST) (Figure S1)

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"The overwhelming amount of death and disease attributable to tobacco is caused by addiction to cigarettes the only legal consumer product that, when used as intended, will kill half of all long-term users," FDA Commissioner Scott Gottlieb said in a statement

This is particularly significant given the alarming trend of increasing youth smokers over the last decade, as highlighted by the Ministry of Public Health of Thailand