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Unobstructed smokers with hernias were more likely to complain of angina but had similar incidences of coronary artery disease, congestive heart failure, diabetes, hypertension, and hyperlipidemia

Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses

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If it works well enough, this would give doctors a lower-dose option for patients who respond without needing the maximum, similar to how many tirzepatide patients do well on 10 mg without going to 15 mg