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Aranda, J

In mouse models of obesity (diet-induced obesity: DIO), levels of FGF15 (the mouse ortholog of human FGF19) are reduced and in humans, serum levels of FGF19 are found to be significantly reduced in patients with type 2 diabetes

Propionyl-L-carnitine in particular may benefit ischemic tissue by replenishing intermediates of energy metabolism or by increasing blood vessel dilation

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Mizushima ( Braf CA/wt mice were crossed with Mieap KO/KO or Atg5 flox/flox , generating Braf CA/wt ,Mieap KO/wt or Braf CA/wt ,Atg5 flox/wt mice, which were subsequently backcrossed to Mieap KO/KO or Atg5 flox/flox mice to produce Braf CA/wt ,Mieap KO/KO or Braf CA/wt ,Atg5 flox/flox mice, respectively