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How long before a marathon should I stop taking semaglutide? If you want peak performance, consider stopping semaglutide 46 weeks before race day the medications half-life is approximately five days, meaning it takes 34 weeks to fully clear your system and another 23 weeks for appetite and gastric emptying to normalize

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Some people may also become more focused on their weight loss goals or body image, which may lead to stress or pressure that affects intimacy

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