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We observed the greatest transcriptional changes induced by GIPR antagonism in the C35 GABA4, C35 GABA3 and C35 Glut10 neurons, which were also among the highest affected neuronal populations targeted by GLP-1R agonism, but not by GIPR agonism

Beyond just reducing obesity, GLP-1 drugs appear to have more direct effects

Much of the heterogeneity in these articles was due to differences in population types, indications for GLP-1 RA treatment, dosages, duration of use, type of GLP-1 RA, fasting times, etc