Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
Inositol assists in converting fat into energy and may help regulate mood
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The inflammatory marker detected was translocator protein (TSPO), the concentration of which, detected by positron-emission tomography (PET), was found to be increased in several brain areas of depressed subjects, including the prefrontal cortex, anterior cingulate, insula, amygdala and others [87,88], signaling widespread neuroinflammation