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However, much of this work was focused on peripheral macrophages 60,61

GH is a counter-regulatory, insulin-antagonistic hormone: sustained elevation reduces peripheral insulin sensitivity, so the pancreas must secrete more insulin to hold blood glucose steady, and fasting glucose tends to drift upward

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This makes it particularly valuable in advanced research where cellular repair, collagen signalling, inflammation response, and tissue regeneration overlap especially in skin and recovery-related models

HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury