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Hormonal shifts as in pregnancy can also cause pigmentation
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Currently, there is a lack of evidence for the involvement of oxidative stress in the pathogenesis of MAFLD mediated by TMAO, but studies on cardiovascular diseases suggest that TMAO is associated with oxidative stress
HSF1 alleviates brain injury by inhibiting NLRP3-induced pyroptosis in a sepsis model
This process occurs in the intestinal L cells of the gastrointestinal tract leading to the co-secretion of GLP-1 and oxyntomodulin in response to nutrient sensing ( Figure 1 Whilst much attention was focused on GLP-1 in the 1980s and 90s, following the discovery of its incretin effect in humans ( Concurrent to the pre-clinical studies, the first human study of oxyntomodulin was carried out in a small double-blind placebo-controlled crossover study ( ad-libitum food intake was significantly reduced in participants receiving OXM compared to saline control and a cumulative caloric intake reduction was observed up to 12 hours later
