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Based on that, its a good practice to look at personal and familial risk of things like cardiovascular disease, stroke, and blood clots before a patient starts hormone therapy

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(2016) Risk of HIV and hepatitis B and C over time among men who inject image and performance enhancing drugs in England and Wales: Results from cross-sectional prevalence surveys, 1992-2013 Journal of Acquired Immune Deficiency Syndromes , 71 :331-337 doi: 10.1097/QAI.0000000000000835 Hope VD, McVeigh J, Smith J, Glass R, Njoroge J, Tanner C, Parry JV, Ncube F, Desai M

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While MR has a much higher affinity to GCs than GR and is at full occupancy at most times of the day, GR mediates more phasic GC effects