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In 2024, gross-to-net margin across GLP-1s ranged from 23% to 45%, indicating that brands were spending over half of their gross sales in rebates, discounts, and affordability programs to achieve maximum access

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There are disputes over how concerning this should be as a side effect, but some studies show as much as 40 to 60 percent of the total weight loss on GLP-1 drugs comes from lean muscle mass