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In this review, we focus on the mechanistic role of the UPS in circadian clock regulation, summarize key E3 ligases and deubiquitinating enzymes implicated in clock protein turnover, and highlight the essential role of the UPS on sleep timing and overall circadian biological homeostasis

A mounting array of studies has revealed that patients with SLE have abnormal metabolism compared to the general population ( In the second part of this analysis (reverse MR), we found that alpha-linolenic acid and linoleic acid were the most significantly enriched metabolic pathways ( p = 0.0260)

Neuropharmacology 37, 15531561.CrossRefGoogle ScholarPubMed Phillips, PH, Glasier, CM, Brodsky, MC (2008)

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The timeline to return to previous weight loss varies based on the re-titration schedule and individual response