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Reducing oxidative stress is important for hair because high free radical activity upregulates the enzyme that converts testosterone to DHT locally, amplifying follicle damage beyond what circulating DHT alone would cause

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It may also cause incontinence, sexual dysfunction, digestive problems, breathing issues, and muscle atrophy

CNS spectrums, 12(10), 739-744.

Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited