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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

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If you've already administered both at full monotherapy doses, stay hydrated, avoid additional food intake until nausea subsides, and monitor blood pressure every 30 minutes