Laboratory blinding as to case and control status occurred for only one research group [65, 76, 87], although others were blinded to case status but not controls, for example, where the laboratory provided the control data [88, 90, 91] or reference ranges [65, 67, 92, 93] or where another study was used for controls [49, 50]
The body attempts to overcome this limitation via the transsulfuration pathway in the liver, which converts the amino acid methionine into cysteine to ensure a steady supply for glutathione synthesis
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Autism Genome Project Consortium: Functional impact of global rare copy number variation in autism spectrum disorders