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From the outside, use of products such as e-cigarettes or heated tobacco may look similar to cigarette use, and there are some similarities

In addition, although the design is pragmatic to include those with psychiatric or substance use comorbidities, trial burden (weekly visits, adherence to the protocol) might make retention problematic for these participants

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Astuti Y, Wardhana A, Watkins J, Wulaningsih W

One study in China reported a low prevalence of past 30-day use of 1.2%, though the study was undertaken in middle-school students instead of high-school students, which could have underestimated teenage e-cigarette use 21