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Specifically, certain efflux transporters like P-gp on astrocytic end-feet, as well as transporters for anions, amino acids, and -amyloid, are downregulated

146 The pathophysiology of addiction has been extensively investigated, revealing drug-induced dysregulation of multiple neural circuits and neurochemical systems, including dopamine, opioid peptides, corticotropin-releasing factor, dynorphin, glutamate, and gamma-aminobutyric acid (GABA)

GLP-1 RAs also delay gastric emptying, which contributes to satiety but may exacerbate symptoms in patients with pre-existing gastroparesis (He et al., 2022

Wang Y, Lu M, Xiong L, Fan J, Zhou Y, Li H, et al

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