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Issue published 30 December 2025 Abstract Background: To determine whether initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within 3 months of type 2 diabetes (T2DM) diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index (BMI)

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Selective endpoint reporting: Studies showing any positive metabolic effectimproved insulin sensitivity, modest glucose reductionsbecome evidence that the supplement works, even when the measured outcome differs entirely from what consumers expect based on pharmaceutical comparisons

GI side effects from the dose increase are typically manageable but present