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A novel cytosolic FADS6 isoform recently characterized contains only the PAPS domain with considerable FAD synthesis activity, which allows survival of affected patients with biallelic FLAD1 frameshift variants [37] .The FADS6 isoform has approximately 70% of the FAD-synthesizing capacity of human FADS2

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Solvation heat (H sol ) was calculated using the following equation: H sol = H tota l H vap , where H total is obtained via the Chrastil model and H vap is derived from the Bartle et al

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