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When the same amount of blood has less oxygen in it, the heart must work harder to deliver needed oxygen to the body

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Based on these reviews, we identified cohort and case-control studies that either reported a measure of association or contained sufficient information to calculate a measure of association between the incidence or mortality of the identified outcomes for tobacco chewers relative to individuals who do not chew tobacco

Tobacco and the Environment Introduction Tobacco kills up to half of its users, this equates to 8 million deaths a year globally and is currently the worlds single biggest cause of preventable death

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