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doi: PubMed: 21325294

found that in human pancreatic ductal adenocarcinoma (PDAC) cell lines, treatment with erastin induced STING1 translocation from the ER to mitochondria and triggered mitochondrial fusion by binding to MFN1/2, which led to increased mtROS levels without triggering PINK1/Parkin-independent mitophagy, eventually causing ferroptosis [117]

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Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone

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