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Similar findings were noted with dipeptidyl peptidase-4 inhibitors in another meta-analysis of 82 RCTs, in which they increased the risk of gallbladder or biliary diseases (OR, 1.22

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Multiple studies suggested that PCOS may further induce serious complications such as diabetes, hypertension, endometrial cancer (EC) and preeclampsia without timely intervention, which can severely affect the quality of life and long-term health outcomes of patients (Krentowska et al., 2021)

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