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Instead of forcing immediate abstinence, methadone provides a controlled and medically supervised way to stabilize the body and mind

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It stimulates the release of dopamine in the brain, reinforcing the desire to keep using tobacco

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The 1985 study by Professor Mats Ericson at KTH Royal Institute of Technology Stockholm, published in the Scandinavian Journal of Rehabilitation Medicine, examined the activity of eleven lower extremity muscles during ergometer cycling in different conditions, finding that vastus medialis and lateralis, gastrocnemius medialis and lateralis, and the soleus were the most activated, with muscle activity varying significantly with changes in work-load, pedaling rate, saddle height, and pedal foot position