& Alarcon-Segovia, D
As ferroptosis is a recently identified form of cell death, research has predominantly employed animal models, and clinical studies targeting ferroptosis in CKD are limited
DHA exposure was assessed using dietary intake estimates, biochemical biomarkers (e.g., plasma, erythrocytes, adipose tissue fatty acid composition), or other biological samples, as reported in each study
This rescue by GSH was not observed after deprivation of other amino acids (serine, glycine, glutamine or glutamate) or after inhibition of amino acid synthesis (via the glutaminase 1 inhibitor CB-839) (Extended Data Fig
Another new insight came from knock-out of the mysterious type 2 IGF receptor, identical to the mannose-6 phosphate receptor (M6P-R), specifically binding IGF-II and involved in internalization of proteins for lysosomal degradation