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"The 'illicit issue' is being used by Big Tobacco as part of a public relations strategy to raise doubts about the effectiveness of standardised packaging, with the aim of derailing legislation. Weak evidence on standardised packaging In February 2014, our researchers found that the deluge of evidence cited by global tobacco companies in response to the government consultation on standardised packaging for cigarettes was either low quality or off-topic

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Another study has found that Rac1 could regulate cigarette smoke-induced pulmonary inflammation in the lung through the STAT3 and Erk1/2 MAPK signaling pathways [120]