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However, a 2022 study in the journal Nutrients found that one of the ingredients in Lemme, Morosil red orange fruit extract, helped participants lose a small amount of weight though notably while also eating a healthy diet and exercising compared to those taking a placebo

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For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Huang et al., 2015