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This biphasic behavior necessitates careful optimization of dosing in any future clinical applications

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Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al

Increased d-lactic acid theory Another theory regarding the reduced intestinal pH and increased gut permeability in ME/CFS patients is the increased production of D-lactic acid due to the overgrowth of Gram-positive bacteria such as Enterococci and Streptococci, which leads to systemic inflammation, immune activation, and oxidative stress [22, 44]

For patients with diabetes and MASLD, SGLT2 inhibitors may offer metabolic and cardiovascular benefits while potentially improving liver health