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Our findings indicate that even very low levels of cigarette smoking are hazardous, supporting public health recommendations that there is no safe level of smoking and that all smokers, including nondaily and very low-intensity smokers, should quit, Inoue-Choi and colleagues wrote.

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That means (that if you take bigger drags more often and seal off the holes) that if you take bigger drags more often and seal off the holes (you consume more harmful components than when you don't do so.) you consume more harmful components than when you don't do so