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A number of brain regions have been identified as targets of nicotine-induced plasticity, including the mesolimbic reward pathway and the amygdala (Adinoff, 2004)

adults aged 40+ years during Wave 5 (20182019) of the Population Assessment of Tobacco and Health Study

Why is this a problem

The cohort was followed from one year after the date of the second health examination to the date of pneumonia hospitalization, death, or until the end of the study period (December 31, 2018), whichever came first

This is exactly why many nicotine-free artificial cigarettes, however well-intentioned, just dont hit the mark for most smokers