They might have decreased kidney function, drug interactions, and more malabsorption issues
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Importantly, BPC 157, but not PDGF-BB, stimulated earlier maturation of granulation tissue, soluble collagen concentration in the exudates (using sponge implantation), and organized collagen significantly more in wounds (i.e., on day 12 after daily treatment) (Tkalcevic et al., 2007)
The chemical co-trimoxazole we used in the study was water soluble, most of the chemical was supposed to remain in the culture supernatant, proper treatment of the supernatant can help lower the risk
However, microbes in the colon can synthesize NAD + de novo from fiber, and microbes in the ileum and jejunum are able to utilize circulating NAM