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On the other hand, the inhibition of Nrf2 signaling might be employed to enhance the sensitization of chemoresistant tumors to cytotoxic agents, and in this context, it has recently been reported that brusatol, a compound found in a plant extract, acts as inhibitor of this pathway and may exhibit therapeutic utility [111]

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ROS are generated by the NADPH oxidase (NOX) enzymes, located on the plasma membrane of cells, notably in neutrophils and vascular endothelial cells