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The major risk factors for angina include: Unhealthy cholesterol levels High blood pressure Anemia Heart failure Cardiomyopathy Metabolic syndrome Smoking Physical inactivity Unhealthy diet Job-related stress Older age (The risk increases for men after 45 years of age and for women after 55 years of age.) Family history of early heart disease Heart procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) Exposure to air pollution Diagnosis You should have a health care professional check out all chest pain