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It is possible to significantly reduce the number of smokers by providing accurate planning and comprehensive training programs on smoking cessation and tobacco use outcomes

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Cardiovascular diseases can have a negative impact on individuals with COPD, causing pulmonary hypertension (PH) [53]

Therefore, the changes in the size and composition of longitudinal bundles in smoking asthmatics may further aggravate airway remodeling by affecting the mechanical properties of the airway or the folding behavior of the airway mucosa 45,83