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Introduction The current tobacco product marketplace is highly diverse and has been evolving over the past decade with the emergence of novel tobacco and nicotine products including electronic cigarettes, heated tobacco products, and oral nicotine pouches (ONPs) ( Tobacco harm reduction (THR) is a public health risk mitigation strategy aimed at reducing the health burden associated with cigarette smoking ( will focus on a regulatory framework that focuses on and supports innovation to promote harm reduction ( Oral nicotine pouches (ONPs) are an emerging category of nicotine products that contain pharmaceutical-grade nicotine, but no tobacco leaf ( Combustible cigarettes exhibit a high degree of abuse liability (AL), a term synonymous with dependence potential ( The AL of a novel nicotine-containing tobacco product is a composite measure based predominantly on the pharmacokinetic (PK) and subjective effects associated with the use of that product ( Materials and methods Study design In three separate randomized, open-label, crossover, in-clinic confinement studies, subjective effects and nicotine uptake of Velo ONPs were evaluated among adult smokers

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For people who smoke and who are using, or are interested in using, a nicotine-containing ecigarette on general sale to quit smoking, explain that: although these products are not licensed medicines, they are regulated by the Tobacco and Related Products Regulations 2016 [footnote 58] many people have found them helpful to quit smoking cigarettes people using ecigarettes should stop smoking tobacco completely, because any smoking is harmful the evidence suggests that ecigarettes are substantially less harmful to health than smoking but are not risk free the evidence on e-cigarettes is still developing, including evidence on their long-term health impact In summary, there is growing evidence that e-cigarettes are helping many thousands of smokers in England to quit

Smokers who are more dependent have been shown to improve their chances of achieving abstinence with the 4-mg gum compared to the 2-mg gum