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Animal models in which the dopamine transporter gene was knocked down or knocked out exhibited an ADHDlike phenotype, which increases activity levels that normalize to wild-type levels with stimulant administration 22

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When nicotine binds to nicotinic acetylcholine receptors (nAChRs), it triggers the release of dopamine and serotonin, two key neurotransmitters associated with feelings of pleasure, reward, and emotional stability

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