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Further studies demonstrate that when GSH is depleted, FSP1 overexpression still exerts cytoprotective effects through a mechanism dependent on the CoQ 10 /NADH cycle, thereby counteracting oxidative stress-induced cellular damage ( 2.5 The GCH1-BH4 pathway: antioxidant regulation by tetrahydrobiopterin Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4)

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RNA analyses