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Human puffing topography, described in detail above, is important in determining true levels of human exposure to constituents in e-cigarettes

Health Impacts The health risks of cigarette smoke are well-documented, ranging from short-term effects like irritation of the eyes, nose, and throat, to long-term risks such as heart disease, stroke, and lung cancer

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For the US market, we anticipate filing later this year a revised modified risk tobacco product [MRTP] application and its related pre market tobacco [PMT] application with the FDAs Center for Tobacco Products for Brand A very low nicotine cigarettes