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By 2050, projections indicate an upward trend in global ASDR, ASDAR, YLLs, and YLD, with the most notable rise among males, with an EAPC of 2.06 (95% CI: 1.342.79), 46.19 (95% CI: 29.7662.62), 24.16 (95% CI: 17.9430.38), and 23.15 (95% CI: 12.7333.58), respectively, according to the ARIMA model (Supplementary file: Figure S10)

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The research points to a clear need for action: without interventions, adult smoking prevalence in Tobacco Nation states is forecasted to be over 40% higher on average over the next 20 years compared to other U.S