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Study revealing that microglia are not required for developmental myelination but instead for limiting myelin growth and demyelination

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documented that MTX caused significant elevations in the activities of aminotransferases, levels of creatinine and malondialdehyde (MDA) and a significant decline in the activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase1 (SOD1) and the level of glutathione (GSH)